Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells

Multiple Roles of MYC in Integrating Regulatory Networks

Figure 1. MYC regulatory networks in pluripotent stem cells. Schematic representation of part of the molecular mechanisms through which MYC affects the PSC identity. MYC supports the pluripotent state by favoring both the typical cell cycle structure and metabolism of PSCs.

Multiple Roles of MYC in Integrating Regulatory Networks

Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells Article (PDF Available) in Frontiers in Cell and Developmental Biology 5 · February 2017 with 45 Reads

Crucial Role of C‐Myc in the Generation of Induced

Luca Fagnocchi and Alessio Zippo, Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2017.00007, 5, (2017).

An Important Role for CDK2 in G1 to S Checkpoint

Luca Fagnocchi and Alessio Zippo, Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2017.00007, 5, …

Roles for MYC in the Establishment and Maintenance of

Several reports also implicate key roles for MYC family members in the maintenance, expansion, and differentiation of stem cell populations including pluripotent stem cells, hematopoietic stem cells, and keratinocyte stem cells (Gandarillas and Watt 1997; Laurenti et al. 2008; Wilson et al. 2008).

Concise Review: Induced Pluripotent Stem Cells as New

Luca Fagnocchi and Alessio Zippo, Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2017.00007, 5, …

Integration of External Signaling Pathways with the Core

Recent works indicate that Oct4 and Sox2, along with c-Myc and Klf4, are sufficient for reprogramming fibroblasts to induced pluripotent stem cells (iPS), which are functionally similar to ES cells (Maherali et al., 2007, Okita et al., 2007, Takahashi and Yamanaka, 2006, Wernig et al., 2007). Hence, these TFs can exert a dominant role in reconstructing the transcriptional regulatory network of ES cells.

Regulatory network control of blood stem cells | Blood Journal

Blood stem cell research has long made use of single cell assays to address fundamental questions such as the self-renewal and differentiation potential of individual cells within heterogeneous cell populations. 41 As outlined above, gene expression is controlled by complex gene regulatory networks, and gene expression measurements can be used to infer the potential nature of those underlying networks.

Published in: Blood · 2015Authors: Berthold GottgensAffiliation: University of Cambridge

Myc Represses Primitive Endoderm Differentiation in

Myc controls multiple aspects of pluripotent stem cell maintenance Introduction Myc is widely regarded as being important for stem cell proliferation, but its role in the regulation of pluripotency remains unclear.

The Sox2-Oct4 Connection: Critical players in a much

Keywords: embryonic stem cells, iPS cells, Sox2, Oct4, transcription factors, proteomics, gene regulatory networks, transcriptional circuitry, DNA repair, reprogramming, self-renewal Introduction Embryonic stem cells (ESC) have had a major impact on the field of stem …

(PDF) Myc orchestrates a regulatory network required for

Pluripotent stem cells (PSCs) are maintained by a complex regulatory network orchestrated by transcription factors, epigenetic modifiers and non-coding RNAs.